Beilstein J. Org. Chem.2019,15, 30–43, doi:10.3762/bjoc.15.3
intermediates mimic single steps of the proposed catalytic cycle in the gas phase. Thus, the charge-tagged catalyst proved one more time its superior effectiveness for the detection and study of reactive intermediates at low concentrations.
Keywords: charge-tag; electrospray ionization; enamineorganocatalysis
Beilstein J. Org. Chem.2017,13, 2577–2583, doi:10.3762/bjoc.13.254
][3][4][5][6][7]. Initially, proline and proline-derived catalysts have been widely used in asymmetric iminium and enamineorganocatalysis [8][9][10][11][12]. Since the beginning of the 21th century imidazolidinone-based organocatalysts developed by MacMillan and co-workers, which are easily
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Graphical Abstract
Scheme 1:
a) MacMillan’s enantioselective α-alkylation of aldehydes. b) Our enantioselective 1,3-chlorosulfen...